14 Mayıs 2012 Pazartesi

Google Alert - chronic prostatitis

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News1 new result for chronic prostatitis
 
New Back Pain Treatment with Unique Dr. Allen's Thermo-Element ...
San Francisco Chronicle
Chronic lower back pain, a debilitating condition that may necessitate ... for prostate treatment: chronic prostatitis and BPH, coronary heart disease, ...

Web2 new results for chronic prostatitis
 
New Thermobalancing Therapy for BPH and Chronic Prostatitis Is ...
New Thermobalancing Therapy for BPH and Chronic Prostatitis Is Free from Negative Side Effects & Does Not Affect Sperm States Fine Treatment. Posted on 6 ...
utahcardiothoracicsurgery.org/.../new-thermobalancing-therap...
Prostate stones found in 40 years old male | dvday.com
The disease is often in patients with benign prostatic hyperplasia, chronic prostatitis and other diseases in an X-ray, B ultrasound and other imaging study ...
dvday.com/prostate-stones-found-in-40-years-old-male/


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Google Alert - prostatitis

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Blogs1 new result for prostatitis
 
Taohe Chengqi Decoction to Treating Chronic Non-bacterial ...
By Medical
Purpose:By the side of the subject in the combined experience of leptin on side (Liu Siphonostegia, wild chrysanthemum, litchi) in the treatment of Chronic Abacterial Prostatitis (CAP) clinic on the basis of good results obtained by animal ...
Medical Research

Web2 new results for prostatitis
 
Ejaculatory Duct Causing pain - Prostatitis Forum & Social Network
Dr. Krongrad can EDO cause pain similar to prostatis? I have had typical prostatitis symtoms for 2 years. I have recently had a TRUS that showed a calcificatio…
prostatitis.ning.com/xn/detail/2201951:BlogPost:32753?xg...
When should I call my doctor if I have prostatitis? - Sharecare
When should I call my doctor if I have prostatitis? Contact your doctor immediately if you have sudden fever, chills and urinary symptoms, such as pain or burning ...
www.sharecare.com/.../when-should-call-doctor-prostatitis


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Google Alert - prostatic hypertrophy

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Web9 new results for prostatic hypertrophy
 
Prostatitis.: Google Alert - prostatic hypertrophy
New Thermobalancing Therapy can terminate benign prostatic hyperplasia (BPH ) or slowly progressive enlargement of the prostate, which makes urination .
prostatitisrewiew.blogspot.com/.../google-alert-prostatic-hypert...
prostatic hyperplasia is a common disease in older men: ldeane.com
Prostatic diseases official tips – Nantong Zhongshan hospital prostate hyperplasia. " " prostatic hyperplasia is a common disease in older men, but in fact for ...
ldeane.com/prostatic-hyperplasia-is-a-common-disease-in-olde...
Can you get Benign Prostatic Hypertrophy (BPH) from masterbating ...
I masterbate AT LEAST 10 times a day. Sometimes wi…
answers.yahoo.com/question/index?qid...
prostatic hypertrophy and other diseases. – hifreehand.com
prostatic hypertrophy and other diseases. Posted by 1002 – May 12, 2012. There is always the patients will ask, what is called external hemorrhoids ...
hifreehand.com/of-prostatic-hypertrophy-and-other-diseases/
is a common disease of older men.Due to prostatic hyperplasia with ...
Male treatment experts said: the most common cause is prostate hyperplasia, prostate hyperplasia and hypertrophy of the prostate, is a common disease of older ...
lisapaging.com/is-a-common-disease-of-older-men-due-to-pro...
a large residual urine | woxingma.com
Prostatic hyperplasia in elderly male friend common frequently-occurring disease , prostatic hyperplasia of male friends caused great trouble, so the hyperplasia ...
woxingma.com/archives/8629
as the age increases the incidence rate is also rising | jiangwenwen ...
Then, we should first know, what causes an enlarged prostate gland enlargement of the prostate gland? What are the reasons? The hypertrophy of the prostate ...
jiangwenwen.com/archives/10763
the bladder muscle will ischemia hypoxia | udaily.cn
Prostatic hyperplasia hyperplasia of prostate pathological analysis and pathology of the prostate in inner and outer two layers: an inner for surrounding the ...
www.udaily.cn/the-bladder-muscle-will-ischemia-hypoxia/
but the current operation therapy remains the treatment of prostatic ...
Many patients are in the online consultation about prostate hypertrophy therapeutic method, hypertrophy of the prostate treatment method which to have?
qinmengqing.com/archives/11834


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Google Alert - benign prostatic hyperplasia

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Blogs3 new results for benign prostatic hyperplasia
 
some benign prostatic hyperplasia can occur in patients with ...
By admin
some benign prostatic hyperplasia can occur in patients with changes in sexual desire. Posted by admin. May 13 2012. Prostatic hyperplasia of the causes and prevention of many Beijing men's concerns about hyperplasia of prostate, causes ...
jardonline.com
is involved in the metabolism of vital organs. | pleaseeathere.com
By admin
The great Chinese medicine on hyperplasia of prostate very early awareness.Think of benign prostatic hyperplasia occurs in the bladder and its etiology and pathology and the Sanjiao are closely related. So for prostatic hyperplasia reasons, ...
pleaseeathere.com
The Study of Diffusion Tensor Imaging in the Prostate Archive ...
By Tumor Research
DTI in the evaluation of prostate pathologies have the potential for providing improved diagnostic information. Purpose:compare the diffusion tensor parameters of prostate cancer, negative normal regions,benign prostatic hyperplasia(BPH) ...
Tumor Research Center

Web10 new results for benign prostatic hyperplasia
 
Approved Drugstore: Benign prostatic hyperplasia and viagra FDA ...
Benign prostatic hyperplasia and viagra . LOW PRICES on herbal viagra online, blue pill, cheap herbal v, little blue v pills for erectile dysfunction and male ...
https://engineering.purdue.edu/SAE/fsae/...old/.../12/?...
with or without edema. Hypertension | kdpf.net
A symptomatic benign prostatic hyperplasia urination, frequent urination is benign prostatic hyperplasia in the early signal, especially the nocturnal increase in ...
kdpf.net/with-or-without-edema-hypertension/
the outer layer is composed of prostate prostate glands ...
Prostatic hyperplasia against what? More and more men diagnosed with prostate hyperplasia, many men on benign prostatic hyperplasia risk understanding is ...
gothamdiaries.com/the-an-outer-layer-is-composed-of-prostate...
Photoselective Vaporisation of the Prostate Using 80-W and 120-W ...
Keywords: Benign prostatic hyperplasia, GreenLight, Laser therapy, ... Recent guidelines also support the use of TURP for the treatment of BPH [5], and [6].
www.europeanurology.com/article/S0302...1/fulltext
Saw Palmetto Study Disappoints – Alternative Medicine For You
Symptoms of BPH can include increased frequency of urination (translation: you need to pee more often) and urgency (you can't wait) but even when the urge to ...
altmedforyou.com/?p=236
urethral discharge | gprock.com
Prostatic hyperplasia although mostly benign disease, but a serious effect on the quality of life in older men, diagnosed with prostate hyperplasia to timely ...
gprock.com/urethral-discharge/
showed fibrous tissue and blood vessels proliferation ...
Hematuria is a common benign prostatic hyperplasia symptoms, mostly manifested as an increase in the number of urine, urinary endless and urinary line ...
sunglassdepartment.com/showed-fibrous-tissue-and-blood-ves...
gland volume was increased | securworks.com
In patients with benign prostatic hyperplasia Consulting: how to treat? I have benign prostatic hyperplasia has been more than a year, always doing the ...
securworks.com/gland-volume-was-increased/
even in their own community to buy drugs or health products from ...
Therefore the early symptoms of benign prostatic hyperplasia for cerebral symptoms ,in addition to a urine flow and urinary line ,there will be intermittent , when ...
ampcass.com/even-in-their-own-community-to-buy-drugs-or-...
difficulty in urination or after sexual intercourse | oceanwavekerry.com
This is due to benign prostatic hyperplasia, prostate disorders, feedback caused by testicular function was enhanced. Life itself for a long time will cause prostate ...
www.oceanwavekerry.com/difficulty-in-urination-or-after-sex...


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Google Alert - acute prostatitis

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Web2 new results for acute prostatitis
 
Prostatitis.: Google Alert - acute prostatitis
Dosage Of Levaquin For Acute Prostatitis. Video GamesVideo GamesVideo GamesVideo GamesVideo Games Generic Levaquin (Levofloxacin) No Prescription ...
prostatitisrewiew.blogspot.com/.../google-alert-acute-prostatitis...
professional treatment of hypertrophy of the prostate for treatment of ...
professional treatment of hypertrophy of the prostate for treatment of acute prostatitis. Posted on May 13, 2012 by admin. With hyperplasia of prostate by ...
kdpf.net/professional-treatment-of-hypertrophy-of-the-prostat...


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Google Alert - prostatis

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Web1 new result for prostatis
 
Effects of clarithromycin on fetus, what is clarithromycin er, prostatis ...
05.05.2012. Prostatis clarithromycin. Order clarithromycin feb 2010 Clarithromycin Sandoz bacterial vaginosis almost twice as active as Clarithromycin is a ...
clarithromycin-inf.tk/prostatis-clarithromycin.html


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Google Alert - bacterial prostatitis

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Web2 new results for bacterial prostatitis
 
Chronic Non bacterial prostatitis for 7 years - ABC Homeopathy Forum
ABC Homeopathy Forum- Chronic Non bacterial prostatitis for 7 years.
abchomeopathy.com/forum2.php/337896/
Amoxicillin for prostatitis
Antibiotics For Chronic Prostatitis. In 1999, the National Institutes of Health redefined prostatitis into four distinct entities: acute bacterial prostatitis . Chronic ...
ssdghadanc.lefora.com/2012/05/12/amoxicillin-for-prostatitis/


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Google Alert - prostat cancer

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News10 new results for prostat cancer
 
Prostate cancer drug resubmitted
Fife Today
The company behind a drug which could extend the lives of men suffering from prostate cancer has asked again for the treatment to be made available to NHS patients. Earlier this year, the Scottish Medicines Consortium (SMC) decided abiraterone was too ...
See all stories on this topic »

Fife Today
Prostate Cancer Screening
phillyBurbs.com (blog)
This FREE screening is available to men ages 50 or older (or 45 and over if African American or have a family history of prostate cancer) who are uninsured or underinsured, not currently under the care of a urologist, and have not had a prostate ...
See all stories on this topic »
Evamere hopes to fill stadium for first-grader with cancer
Hudson Hub-Times
But 7-year-old Tucker Gromosiak has more on his young mind than imaginable -- prostate cancer. Tucker, a first-grader at Evamere Elementary School, was diagnosed earlier this spring with stage three prostate cancer. Stage three means the disease has ...
See all stories on this topic »
West Van photo exhibit brings awareness to prostate cancer
News1130
WEST VANCOUVER (NEWS1130) - Pictures of famous Canadians affected by prostate cancer are on display this weekend in West Vancouver. "TIEd Together" features 100 intimate portraits of notables like Pierre Trudeau, Brett Wilson and Preston Manning.
See all stories on this topic »
SCOTS MAY BE GIVEN MEGRAHI CANCER PILL
Express.co.uk
This is despite prostate cancer being the most common cancer among Scottish men, affecting 19000 people and causing around 800 deaths a year. Now the drug, which has been credited with prolonging the life of Abdelbaset Ali Mohmed al-Megrahi, ...
See all stories on this topic »
Upcoming health & wellness events
Detroit Free Press
Prostate cancer support group: 7 pm Josephine Ford Cancer Center-Downriver, 19675 Ford, Allen Park. 734-379-9434. Stroke seminar: Time Lost is Brain Lost!: There will be a panel of experts, robot demonstration, screenings and a question-and-answer ...
See all stories on this topic »
Alan Cassels: How perfectly healthy people are turned into patients
The Province (blog)
Or a PSA test for prostate cancer? Even a full body CT scan? Finding the signs of illness before it strikes you down is always the best course of action – isn't it? You might have similar thoughts when offered a routine screening test, ...
See all stories on this topic »

The Province (blog)
Testosterone drug use growing despite risks
San Francisco Chronicle
Testosterone replacement has long been prescribed for men who suffer from abnormally low levels of the male sex hormone, but overuse can lead to infertility and can even speed the growth of prostate cancer. That hasn't stopped Michael Murray, ...
See all stories on this topic »
Mom lost to cancer, daughter continues her life lessons with her own
Boyertown Berk Montgomery Newspapers
Her husband's father, Daniel Arnold, was diagnosed with prostate cancer about a year or two ago. "Being involved with Relay honors my mother in many ways. My mom was misdiagnosed for quite some time, before the doctors caught her leukemia.
See all stories on this topic »
Surgery robot introduced at Ottawa Hospital
CBC.ca
"We've had great success with helping 100 prostate cancer and gynecologic cancer patients, but we feel this is only going to get better as our program improves, as we expand to other cancers," said Rodney Breau, a surgical oncologist at the Ottawa ...
See all stories on this topic »

CBC.ca

Web3 new results for prostat cancer
 
Prostatitis.: Google Alert - prostat cancer
Prostatitis.: Google Alert - prostat cancer. By David Templeton / Pittsburgh Post- Gazette Short of a cure, the Holy Grail in prostate-cancer treatment is determining ...
prostatitisrewiew.blogspot.com/.../google-alert-prostat-cancer_...
Prostatitis.: Google Alert - prostat cancer
(Credit: "test tubes" image via Shutterstock) U. PITTSBURGH (US) — The detection of certain gene abnormalities in the blood or tumor tissue of prostate cancer ...
prostatitisrewiew.blogspot.com/.../google-alert-prostat-cancer_...
Prostatitis.: Google Alert - prostat cancer
PROSTATE cancer patients are to be denied a life-extending drug used to treat Abdelbaset Also Mohmed Al Megrahi, the Lockerbie bomber. By Stephen Adams ...
prostatitisrewiew.blogspot.com/.../google-alert-prostat-cancer_...


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Google Alert - prostatic hyperplasia

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Web2 new results for prostatic hyperplasia
 
Prostatitis.: Google Alert - benign prostatic hyperplasia
some benign prostatic hyperplasia can occur in patients with changes in sexual desire. Posted by admin. May 13 2012. Prostatic hyperplasia of the causes and ...
prostatitisrewiew.blogspot.com/.../google-alert-benign-prostati...
prostatic hyperplasia is a common male disease | packoem.com
winter diseases in summer for " prostatic hyperplasia is a common male disease, mostly concentrated in the age of onset after the age of 50, and increased with ...
packoem.com/prostatic-hyperplasia-is-a-common-male-disease/


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Google Alert - chronic prostatitis treatment

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News1 new result for chronic prostatitis treatment
 
New Back Pain Treatment with Unique Dr. Allen's Thermo-Element ...
DigitalJournal.com
Fine Treatment exclusively offers Dr Allen's devices for prostate treatment: chronic prostatitis and BPH, coronary heart disease, dissolving kidney stones, ...


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Google Alert - treatment for prostatitis

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Web1 new result for treatment for prostatitis
 
CHIROPRACTIC TREATMENT FOR PROSTATITIS
CHIROPRACTIC TREATMENT FOR PROSTATITIS. Prostatitis is defined as an inflammation or swelling of prostate that can be minor or intense problem in ...
www.changingcallcenters.com/.../chiropractic-treatment-for-pr...


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Google Alert - prostatitis diet

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Web4 new results for prostatitis diet
 
Supplememnts Can Increase Windows 7 Home Premium Your ...
Dietary supplements for prostate illness aren't cures, they might be day to day as great as vitamins as great as minerals which could await have firm a man's ...
xikv.com/pregnant/24777.html
Supplememnts Can Improve Windows 7 Ultimate Your Prostate ...
supplements for prostate wellness. Sustaining a wholesome prostate is simple Windows 7 Ultimate adequate nowadays with all of the dietary supplements and ...
artyapt.com/.../supplememnts-can-improve-windows-7-ultimat...
Supplememnts Can Strengthen Office 2010 Your Prostate Well ...
Dietary supplements for prostate well being aren't cures, they are routines and vitamins and minerals which can assist improve a man's prostate health and ...
www.chocolateafterglow.com/.../supplememnts-can-strengthen...
Supplememnts Can Increase Windows 7 Home Premium Your ...
dietary supplements for prostate well being. Preserving a healthy prostate is easy Office 2010 sufficient lately with all the dietary dietary supplements and herbal ...
answers.apostoliccm.com/.../supplememnts-can-increase-wind...


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Battling depression with "battery-powered brains" - CNN report on deep brain stimulation (DBS)

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CNN reports on treating severe depression with electrodes inside the brain:



The procedure -- called deep brain stimulation, or DBS -- targets a small brain structure known as Area 25, the "ringleader" for the brain circuits that control our moods.

Area 25 is relatively overactive in depressed patients. One hypothesis is that in patients who do not improve with treatments for depression, Area 25 is somehow stuck in overdrive.

DBS had been used since 1997 as a treatment for movement disorders, including essential tremor, Parkinson's disease and dystonia.

References:

Treating depression with electrodes inside the brain. CNN, 2012.

Understanding Healthcare Power of Attorney - Cleveland Clinic video

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This is very important: Advance directives are legal documents that provide instructions about who should oversee your medical treatment and what your end-of-life wishes are, in case you are unable to speak for yourself.

Advance directives include:

- Health Care Power of Attorney
- Living Will



Everyone over the age of 18 should consider assigning Health Care Power of Attorney to someone.

The 21 genetic conditions that should be reported by patients if found incidentally during whole-genome sequencing

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Illustration: DNA associates with histone proteins to form chromatin. Image source: Wikipedia.

There are no established guidelines on which genetic variants should be presented to physicians as incidental findings from whole-genome sequencing. A recent study showed that genetic specialists agreed that pathogenic mutations for 21 common genetic conditions should be disclosed by patients.

For adult patients

APC-associated polyposis
Fabry disease
Familial hypercholesterolemia
Galactosemia
Gaucher disease
Glycogen storage disease type IA
Hereditary breast and ovarian cancer
Homocystinuria
Li-Fraumeni syndrome
Lynch syndrome
Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 2
MYH-associated polyposis
Phenylketonuria
Pompe disease
PTEN hamartoma tumor syndrome
Retinoblastoma
Romano-Ward (long QT syndrome)
Tyrosinemia type 1
Von Hippel-Lindau disease
Wilson disease

For pediatric patients (child)

PTEN hamartoma tumor syndrome
Retinoblastoma
Romano-Ward (long QT syndrome)
Von Hippel-Lindau disease

Collecting family history predicts cancer risk better than 23andMe genetic testing, according to a recent study from the Cleveland Clinic:



References

Exploring concordance and discordance for return of incidental findings from clinical sequencing. Green RC, Berg JS, Berry GT, Biesecker LG, Dimmock DP, Evans JP, Grody WW, Hegde MR, Kalia S, Korf BR, Krantz I, McGuire AL, Miller DT, Murray MF, Nussbaum RL, Plon SE, Rehm HL, Jacob HJ. Genet Med. 2012 Apr;14(4):405-10. doi: 10.1038/gim.2012.21. Epub 2012 Mar 15.

Genome sequencing to add new twist to doctor-patient talks. American Medical Association, 2012.

How to talk to patients about genetic testing  http://goo.gl/kkW4m

"You take what you need and you leave the rest, But they should never have taken the very best"

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"You take what you need and you leave the rest, But they should never have taken the very best" is a refrain from The Night They Drove Old Dixie Down, one of the best known songs of The Band.



Levon Helm, the revered drummer and singer of group the Band who kept the band's heart for more than three decades, died "peacefully" on April 19.

From CNN:

Born in Elaine, Arkansas, in 1940, the son of a cotton farmer, Helm rose to fame in the late 1960s and 1970s as a member of The Band, a folk rock group.

His soulful, drawling vocals highlighted many of the group's hit recordings, such as "The Weight," "The Night They Drove Old Dixie Down," and "Up on Cripple Creek."

Helm, 71, was diagnosed with throat cancer in 1998. He fell on hard times as cancer took his voice and medical bills threatened his house.

"You got to pick one -- pay your medical bills or pay the mortgage. Most people can't do both, and I'm not different," he told CNN in 2010.

So The Barn, as the residence is known around Helm's adopted hometown of Woodstock, New York, became the setting for what he called a "last celebration." Not quite. Instead, The Barn became the center of an unlikely and unrivaled rock 'n' roll revival.

It was there that Helm regularly hosted the Midnight Ramble, weekly concerts that attracted sell-out crowds and all-star support. The result not only paid the bills but also led to a creative resurgence for Helm, with his collaborations producing back-to-back Grammy-winning albums: 2007's "Dirt Farmer" and 2009's "Electric Dirt."

"If I had my way about it, we'd probably do it every night," Helm said. "I never get tired of it."

From Wikipedia:

Helm remained with "The Band" until their 1976 farewell performance, The Last Waltz, which was recorded in a documentary film by director Martin Scorsese (an excerpt is embedded above). Many music enthusiasts know Helm through his appearance in the concert film, a performance remarkable for the fact that Helm's vocal tracks appear substantially as he sang them during a grueling concert.

In the late 1990s, Helm was diagnosed with throat cancer suffering hoarseness. Advised to undergo a laryngectomy, Helm instead underwent an arduous regimen of radiation treatments at Memorial Sloan–Kettering Cancer Center in New York City. Although the tumor was then successfully removed, Helm's vocal cords were damaged, and his clear, powerful tenor voice was replaced by a quiet rasp. Initially Helm only played drums and relied on guest vocalists at the Rambles, but Helm's singing voice grew stronger. On January 10, 2004, he sang again of his Ramble Sessions. In 2007, during production of Dirt Farmer, Helm estimated that his singing voice was 80% recovered.

The Midnight Ramble was an outgrowth of an idea Helm explained to Martin Scorsese in The Last Waltz. Earlier in the 20th century, Helm explained, traveling medicine shows and music shows such as F.S. Walcott Rabbit's Foot Minstrels, featuring African-American blues singers and dancers, would put on titillating performances in rural areas. This was also turned into a song by the Band, "The W.S. Walcott Medicine Show," with the name altered so the lyric was easier to sing.

"After the finale, they'd have the midnight ramble," Helm told Scorsese. With young children off the premises, the show resumed: "The songs would get a little bit juicier. The jokes would get a little funnier and the prettiest dancer would really get down and shake it a few times. A lot of the rock and roll duck walks and moves came from that."

Helm has refused to play The Night They Drove Old Dixie Down since 1976 even though he continued to hold "Midnight Rambles" concerts several times a month at his private residence in Woodstock, New York.



References:

Fans remember Levon Helm as he faces final stages of cancer. CNN.
Levon Helm, co-founder of The Band, dead at 71. CNN.
Levon Helm, icon of Americana music, 'in the final stages of cancer'. Guardian.
Fauquier ENT Blog: Levon Helm, Singer/Drummer for The Band, Dies of Throat Cancer  http://goo.gl/tDgxL
Levon Helm. Wikipedia.

Mayo Clinic Offers Dietary Supplements, Stress Management, Massage and Acupuncture in the Mall of America

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Cleveland Clinic has a Wellness Institute. In another push to the realm of wellness, Mayo Clinic now offers one-on-one consults with Complementary and Integrative Medicine physicians on campus and where the customers are - right in the Mall of the America. See this 3-part video series below:



Brent A. Bauer, M.D. Dr. Bauer is a physician in the Department of General Internal Medicine and supervisor of the Complementary and Integrative Medicine Research program at Mayo Clinic.



Nancy Drackley, a physical therapist, massage therapist, and supervisor of massage therapy at Mayo Clinic.



Tony Chon, M.D, a physician in the Department of General Internal Medicine and a member of the Complementary and Integrative Medicine team at Mayo Clinic, discusses acupuncture.

Unfaithfulness in men may be associated with higher risk of cardiovascular events

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The authors of this study from Italy performed an extensive Medline search for “unfaithfulness,”“extramarital affairs,”“infidelity,” and “men.”

How common is unfaithfulness in men?

As expected the results were variable. Some surveys reported that 1.5–4% of married men had extramarital coitus in any given year, others that 23.2% of men have cheated during their current relationship.

Lifetime prevalence of unfaithfulness was between 15% and 50%.

What are the factors related to unfaithfulness?

Men with extramarital affairs more frequently have a dysfunctional primary relationship.

Parenthood and conflicts within the family are associated with a higher risk of having an affair.

Unfaithful men display a higher androgenization, larger testis volume, higher sexual desire, and better sexual functioning.

What are the clinical implications of unfaithfulness in men?

Some studies have suggested that having an extramarital affair could have a negative impact on cardiac morbidity and mortality. Unfaithfulness in men seems to be associated with a higher risk of major cardiovascular events.

References

Fisher AD, Bandini E, Rastrelli G, Corona G, Monami M, Mannucci E, and Maggi M. Sexual and cardiovascular correlates of male unfaithfulness. J Sex Med, 2012.

Image source: OpenClipart.org, public domain.

Diabetes drug injected once a week gets F.D.A. approval: Bydureon (long-acting exenatide)

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From the NYTimes:

The FDA twice declined to approve long-acting exenatide (Bydureon) in 2010, with its most serious concern being that the drug might contribute to heart rhythm abnormalities. There are safety concerns involving thyroid cancer and pancreatitis.

Bydureon is a longer-lasting version of Amylin’s existing drug Byetta, which is injected twice a day. Another company, Alkermes, supplied the technology that slowly releases Bydureon inside the body.

Bydureon, Byetta and Victoza are drugs called GLP-1 receptor agonists, which mimic the effect of glucagonlike peptide- 1, a hormone that increases insulin production when blood sugar is high.


Figure: Action of DPP-4 inhibitors. Note that DPP-4 normally inactivates GLP-1. DPP-4 inhibitors block DPP-4 which in turn leaves GLP-1 active. Click to enlarge the figure. I made the figure with Gliffy in 2006 . The diagram Action of DPP-4 inhibitors is now widely used in many articles on Wikipedia, with my permission.

The main ingredient in both Bydureon and Byetta is exenatide, a hormone derived from the saliva of the Gila monster, a poisonous lizard found in the Southwestern United States and Mexico.

Wholesale price of Bydureon would be $323 for 4 doses, or about $4,200 a year. That is between the roughly $3,400 for the low dose of Victoza and $5,000 for the high dose.

References:

Diabetes Drug Injected Weekly Wins F.D.A. Approval. NYTimes.

Comments from Twitter:

Vaughn Eyvazian @Vaughnsays: Increase that pt compliance!

Reinaldo B. @basanezrx: but nobody stays in the lowest dose of Victoza in my experience, and that's why most ins companies pay for Byetta instead. A shame :(

Top articles in medicine in April 2012

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Here are my suggestions for some of the top articles in medicine in April 2012:

Rise in Scientific Journal Retractions Prompts Calls for Reform - NYTimes http://goo.gl/6qB8H. The higher a journal’s impact factor, the higher its retraction rate. The highest “retraction index” naturally belongs to NEJM. Retractions are “a symptom of a dysfunctional scientific climate”. Each year, every laboratory produces a new crop of Ph.D.’s, who must compete for a small number of jobs, and the competition is getting fiercer. In 1973, more than half of biologists had a tenure-track job within six years of getting a Ph.D. By 2006 the figure was down to 15 percent. Yet labs continue to have an incentive to take on lots of graduate students to produce more research (“pyramid scheme”).

Harvard University says it can't afford journal publishers' prices: $3.5m a year, 145% increase over 6 years http://goo.gl/tlxWP

Warren Buffett may be the richest man in America, but he appears to be getting the poorest medical advice. In medicine, "watchful waiting" is now called "active surveillance with delayed intention to treat" - Harvard http://hvrd.me/JsK3vK

Lab Testing in Erectile Dysfunction: glucose, testosterone, prolactin, and lipid profile may reveal comorbidities http://goo.gl/MdBrn

75% of diabetics who had gastric bypass surgery no longer were diabetic after 2 years. Bariatric surgery costs $18,000-35,000 without insurance - for those with coverage, $5,000 deductibles are common j.mp/Ie0xYl

30% of U.S. workers are not getting enough sleep - 41 million sleep 6 or fewer hours putting the public at risk http://goo.gl/mnQJg

Survey lists "Best Paid and Worst Paid Doctors". Only 11% of U.S. doctors consider themselves rich. 45% of doctors think: "My income probably qualifies me as rich, but I have so many debts and expenses I don't feel rich." http://goo.gl/a5gq8

Among children and adolescents in a low-income, urban area, text messaging increased rate of influenza vaccination http://goo.gl/waznJ

Most major British universities are paying £4-6 million a year to journal publishers like Elsevier, Springer, etc. Most publishers have to pay for content they publish. Not journal publishers. Content is provided free by researchers. The peer reviewing that ensures quality of publications is provided free (value of UK unpaid peer reviewing is £165m) http://bit.ly/HYzonu

The articles were selected from my Twitter and Google Reader streams.

What is the minimal webmaster competence for running a medical blog?

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"What is the minimal webmaster competence for running a medical blog?", asked a relatively new blogger recently. My suggestions are listed below.

Keep it simple, and free

If your blog content is great and compelling, you don't need much HTML, CSS, etc. knowledge. Knowing HTML doesn't hurt, of course, but it's not essential.

Keep it simple, and free. Many doctors are wrongly advised to spend time and money on custom installations of WordPress, hosting, and social media consultatants when all they need is a free Google/Blogger blog with a custom domain name.

"Blogging is teaching, whether it’s yourself or others, and that’s the best feeling in the world" 

Speaking from personal experience, my blogs reached more than 8 million page views and I've never used outside help for blog launch or maintenance. I don't think my blog content is that great or original apart from a few mind map diagrams, mnemonics and social media how-to articles - it's just my personal digital netbook that I share with the world.

I typically publish one post per day during the week at CasesBlog and AllergyNotes. They are scheduled 2-3 months in advance, and publish automatically, unless I edit them the day before they are due for posting.

"Blogging is teaching, whether it’s yourself or others, and that’s the best feeling in the world" http://goo.gl/hCpF8

Comments from Google Plus:

Ahmad Gandour, Jan 25, 2012: This is a great advice i will consider starting a blog in the near future .you really post interesting post i check your post every day in the morning while i am checking journal watch and BEJM news letter thanks for these great post .

Ves Dimov, M.D., Jan 25, 2012: Thank you for your interest. I typically publish one post per day during the week at CasesBlog and AllergyNotes. They are scheduled 2-3 months in advance, and publish automatically, unless I edit them the day before they are due for posting.

Ahmad Gandour, Jan 25, 2012: Thanks for the info i booked marked the both pages i am going to check it every day

Ves Dimov, M.D., Jan 25, 2012: You can subscribe to the RSS feeds - this way there is no need to visit the website every day - the new post gets delivered to your RSS reader (Google Reader) or email.

Ahmad Gandour, Jan 25, 2012: Done :)

Jill Celeste, Jan 25, 2012: Blogger is the perfect tool for a doctor. Great post!

Memory loss - clinical focus on practical neurology

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These are excerpts from a review in the Medical Journal of Australia (MJA):

Older people with mild cognitive impairment are at increased risk of progressing to dementia, but no tests are helpful in assessing this risk. Medications are not beneficial in mild cognitive impairment.

Physical activity and treatment of hypertension decrease the risk of dementia.

In people with Alzheimer’s disease, a cholinesterase inhibitor or memantine (an N-methyl- D-aspartate receptor antagonist) provides symptomatic relief. Medications do not change progression of the illness.

Behavioural and psychological symptoms are common in Alzheimer’s disease.

Atypical antipsychotics reduce agitation and psychosis but increase the risk of cardiovascular events.

Antidepressant role in managing depression with mild cognitive impairment is uncertain but they may increase the risk of delirium and falls.

References:

Memory loss. Leon A Flicker, Andrew H Ford, Christopher D Beer and Osvaldo P Almeida. Med J Aust 2012; 196 (2): 114-117.

Image source: Hippocampus, from Wikipedia, public domain.

The Diet Factor in Attention-Deficit/Hyperactivity Disorder - State-of-the-Art Review Article in Pediatrics

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Diets that were tried in attempt to reduce symptoms associated with attention-deficit/hyperactivity disorder (ADHD) include:

- sugar-restricted
- additive/preservative-free
- oligoantigenic/elimination
- fatty acid supplements

Omega−3 supplement is the latest dietary treatment with positive reports of efficacy. Interest in the additive-free diet of the 1970s is occasionally revived.

Provocative reports have drawn attention to the ADHD-associated “Western-style” diet, high in fat and refined sugars, and the ADHD-free “healthy” diet, containing fiber, folate, and omega-3 fatty acids.

Indications for dietary therapy include:

- medication failure
- parental or patient preference
- iron deficiency
- change from an ADHD-linked Western diet to an ADHD-free healthy diet, when appropriate

In practice, additive-free and oligoantigenic/elimination diets are time-consuming and disruptive to the household; they are indicated only in selected patients.

Iron and zinc are supplemented in patients with known deficiencies; they may also enhance the effectiveness of stimulant therapy.

In patients failing to respond or with parents opposed to medication, omega-3 supplements may warrant a trial.

References:

The Diet Factor in Attention-Deficit/Hyperactivity Disorder. J. Gordon Millichap, MD and Michelle M. Yee, CPNP. PEDIATRICS Vol. 129 No. 2 February 1, 2012, pp. 330 -337, (doi: 10.1542/peds.2011-2199)

Image source: Olive oil, Wikipedia

Best of Medical Blogs - weekly review, blog carnival

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The “Best of Medical Blogs - weekly review, blog carnival” is a weekly summary of the best posts from medical blogs. Feel free to send your suggestions to my email at clinicalcases@gmail.com. Best of Medical Blogs is published every Tuesday, just like the old Grand Rounds.

Social Networks for Doctors: Are We There, Yet?

Twitter can be as inane, or as useful, as the accounts you follow. Sure, doctors use Facebook like everyone else, but – by and large – they haven’t tapped into the educational potential that online social networks offer. Once viewed as a trivial hobby by more eminent researchers and writers, blogs now serve as the elder statesmen of social media - and they can act as a base of operations for social networking. An excellent summary by Shiv Gaglani & Nicholas Genes: http://goo.gl/9DVbI

A Twitter Primer for Physicians (aka Twitter 101 for Docs)

Here are Dr. Ryan Madanick's suggestions: http://goo.gl/gNS5d. Dr. Madanick is a gastroenterologist at the University of North Carolina School of Medicine, as well as the Program Director for the GI & Hepatology Fellowship Program.

1. Consider starting with a private account.

2. Start following some accounts: Specialty societies and journals, let Twitter suggest some accounts, search for accounts with similar interests.

3. Listen to what others are saying.

4. Decide what to tweet.

5. Find a hashtag.

The incredible frailty of life

Realizing the incredible frailty of life and the battle to avoid irrational exuberance: a journey into the NICU as a Med-Peds uncle. This is a heartfelt article by Dr. Moises Auron from Cleveland Clinic: http://goo.gl/KvUbN

The NYTimes gets it wrong on ECG screening of young athletes

Dr. John Mandrola, a cardiac electrophysiologist, comments on a NYTimes article that included numerous inaccuracies and failed to tell important facts about the complexities of widespread screening of athletes. http://goo.gl/siEEp

How one patient uses Social Media

"Personally.. I don’t want to be a patient.. It’s totally the last thing I want to be…Before my diagnosis I shamefully has no idea what Rheumatoid arthritis (RA) was or what the consequences were of having a Chronic Illness. Patients and Doctors will find a solution together." A guest post at Dr. Ronan Kavanagh's blog. Dr. Kavanagh is rheumatologist from Ireland: http://goo.gl/daRfd

Krokodil is a devastating homemade opiate

Krokodil (or crocodile) refers to homemade batches of the opiate desomorphine (currently available without a prescription in Russia), and ingredients such as gasoline, paint thinner, hydrochloric acid, iodine, and red phosphorous. When injected, this highly impure mixture often causes skin to turn greenish grey and scaly, which may explain the drug’s name. Another explanation is that subsequent ischemia, gangrene and amputation has the same effect as a crocodile biting off a victim’s limb. From The Poison Review: http://goo.gl/VAq28

How to straighten a guidewire with one hand

The Australian blog Life in the Fast Lane is one of the best blogs focused on emergency medicine. Here is one of their shorter posts: How to straighten a guidewire with one hand http://goo.gl/mC9zY

GruntDoc: It’s my 10th Blogging Anniversary http://goo.gl/TkBc7 - Congratulations! A great reflection on a long journey.

10 Bad Assumptions Patients Make - a post by Dr. Rob http://goo.gl/EpmUO

All papers at PLoS Medicine now reflect the public Twitter debate | Medical Museion http://goo.gl/Xmu5Y

Caffeine and Sleep In Kids: It is a good rule of thumb to avoid soda entirely | Craig Canapari, MD http://goo.gl/W5HGS

Using fruit to improving anaphylaxis care - use your expired injectable epinephrine on an orange, an allergists suggest http://goo.gl/AQIxw

Are we too concerned with confidentiality? Former BMJ editor provides a personal example: http://goo.gl/0J3dp

Comments from Twitter:

John Mandrola, MD @drjohnm: Thx 4 shout out. Wow, lots of other great posts.

Mike Cadogan @sandnsurf: Concise, pithy and diverse - great read

Craig Canapari @DrCanapari:  Honored to be included

Diary-Writing Has Psychological Benefits - Journal of Happiness Studies

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Writing has long been used as a coping strategy and has been applied to improve psychological well-being. One study found that suicidal poets used more first-person singular pronouns (I, me, my) than the control group of poets.

This study from Taiwan, published in the Journal of Happiness Studies, investigated the psychological displacement paradigm in diary-writing (PDPD) and its supposed psychological benefits.

Study participants were randomly assigned to write about their recent negative life experiences two times a week for 2 weeks in PDPD group (diary-writing), or comparison group (no diary-writing).

The diary-writing group (PDPD) showed a decrease in negative emotion and an increase in positive emotion immediately after each writing session (short term effect).

They also had an increase in psychological well-being for at least 2 weeks (long term effect).

References:

The Psychological Displacement Paradigm in Diary-Writing (PDPD) and its Psychological Benefits. Jen-Ho Chang, Chin-Lan Huang and Yi-Cheng Lin. JOURNAL OF HAPPINESS STUDIES 2012, DOI: 10.1007/s10902-012-9321-y

Comments from Google Plus and Twitter:

Lin W: I guess blog writing might have the same effect?

Ves Dimov, M.D.: It depends on the type of blogging you do, but yes, blogging can be a positive experience too.

Dr. Amal Hasan @DrFloona: Diary-Writing Has Psychological Benefits bit.ly/wwMDmr” Until someone else reads it

Dean Giustini @giustini: Diary-Writing Has Psychological Benefits bit.ly/wwMDmr [Isn't this why we blog Ves?]

@DrVes: Well, I'm not sure. I don't blog about "negative experiences". Blog = archive for me

Dermatology Art Contest by Mayo Clinic shows that art can be seen in every aspect of life

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A Mayo Clinic dermatology art contest shows beauty really is skin deep. From Mayo Clinic News blog:

A hair follicle or skin specimen that doesn’t look like much of anything to the naked eye can become a complex, colorful work of art under a microscope. The winner of the Mayo dermatologists’ first art contest in 2011 was “Hair Follicle Triplet”. Alexander Meves, M.D., used fluorescent dyes to highlight proteins. The inaugural winners of the art contest appeared in the May issue of the Journal of Cutaneous Pathology.

“Every single day, dermatopathologists get to see beautiful images under the microscope, and most people never have the opportunity to see that. So I thought it would be a nice way to show not only the science of dermatopathology, but also the art,” says the contest’s creator, Dr. Lehman, a Mayo Clinic dermatopathologist.



Dr. Lehman hopes medical societies will run with the idea and hold similar competitions to highlight aesthetics in their specialties. People in other lines of work can also celebrate the beauty of what they do each day, she says.

Editor's note: Allergists should do something similar. We already highlight beautiful pollen allergens on the monthly covers of the ACAAI journal.

“Art can be seen in every aspect of life,” Dr. Lehman says. “You just have to have an open mind and be looking for it.”

References

Dermatology Art Shows Beauty Really Is Skin Deep. Mayo Clinic News.

Healthcare social media - top articles

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Here are my suggestions for some of the top articles related to healthcare social media in the past 2 weeks:

Healthcare social media is a moral obligation

Healthcare social media is a 'moral obligation', says Farris Timimi, M.D., medical director for the Mayo Clinic Center for Social Media. Social media needs to be grown and nurtured for patients. "Our patients are there. Our moral obligation is to meet them where they're at and give them the information they need so they can seek recovery," Timimi said. "You've got to be ready for it. You build it for the patients; not for yourself. "This is not marketing," he added. "This is the right thing to do." http://goo.gl/BHzKf

The New World Of Medical Tweeting

300 million users generate 300 million messages every day, and doctor are part of it. 38% of tweets are conversational - transferring information and spreading content. Twitter can be a strong educational tool.

The American Medical Association has released a public statement about professionalism in social media:

“Participating in social networking and other similar internet opportunities can support physicians’ personal expression, enable individual physicians to have a professional presence online, foster collegiality and camaraderie within the profession, provide opportunity to widely disseminate public health messages and other health communication." http://goo.gl/K2QtK

Guidelines for social media use by Federation of State Medical Boards (FSMB) describe in detail what NOT to do: http://goo.gl/Raq2e

Digital Strategies for Healthcare Organisations http://goo.gl/PZtWl

Use of Social Media by Western European Hospitals: Longitudinal Study shows that SoMe awareness is growing http://goo.gl/l41tz

Doctors can risk lawsuits when writing about patients - amednews points to books about patients as examples http://goo.gl/QhqFS

GruntDoc: It’s my 10th Blogging Anniversary http://goo.gl/TkBc7 - Congratulations! A great reflection on a long journey.

The articles were selected from my Twitter and Google Reader streams.

Top articles in medicine in May 2012

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Here are my suggestions for some of the top articles in medicine in May 2012 so far:

Is Geriatric Medicine Terminally Ill? asks Annals of Internal Medicine http://goo.gl/J4jMU

Low vitamin D (below 50 nmol/L (20 ng/mL) increases risk for clinical disease among older adults http://goo.gl/tBXS4

Senior physicians keep working, putting off the R-word - 20% of U.S. physicians are older than 65 http://goo.gl/Dxgip

Many young doctors worried about future of medicine - amednews http://goo.gl/r61lW

"One of the greatest risks of social media is ignoring social media" says chief integrity officer of Cleveland Clinic. Patients want to use social media tools to manage health care http://goo.gl/9SAry

Doctors can risk lawsuits when writing about patients - amednews points to books about patients as examples http://goo.gl/QhqFS

Coffee is the most complex food known to man. It has 1200 flavor components. The nearest comparison is red wine with 450 chemical compounds in the flavor make-up. In most commercial blends there are 10 to 12 different coffees, from different farms. http://goo.gl/m2LwD

Guidelines for social media use by Federation of State Medical Boards (FSMB) describe in detail what NOT to do: http://goo.gl/Raq2e

Prevention of acute knee injuries in adolescent female football (soccer) players: warm-up could help http://goo.gl/dBgSS

Is It Possible To Walk And Work At The Same Time? Kaiser Permanente tries walking meetings http://goo.gl/cRu8l

Corneal transplantation - 2012 state of the art review in The Lancet http://goo.gl/JBAag

Towards an optimum strategy in rheumatoid arthritis: For RA patients who fail initial methotrexate treatment, add-on disease-modifying antirheumatic drugs are appropriate http://goo.gl/ONq6u

Time Spent Behind the Wheel May Increase Heart Health Risks, linked to less time spent exercising http://goo.gl/NUYX7

Recipe For Safer Drinking Water (from bacteria)? Add Sun, Salt And Lime http://goo.gl/kU2ZK

The articles were selected from my Twitter and Google Reader streams.